Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
- 19 October 2003
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 6 (11) , 1137-1138
- https://doi.org/10.1038/nn1137
Abstract
We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopolysaccharide, but their pyretic capacity in response to centrally administered PGE2 was intact. Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain.Keywords
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