Effect of anticonvulsant therapy on serum 25-hydroxyvitamin D level.

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Abstract
Serum 25-hydroxyvitamin D levels in young patients receiving anticonvulsants were assayed. They had neither retardation of physical and psychomotor development nor malnutrition. The patients treated with phenobarbital alone revealed rather high levels of serum 25-hydroxyvitamin D during 2 mo. after institution of the therapy, then they gradually returned to the normal level by the end of 3-5 mo. and thereafter decreased further, while a marked decrease of serum 25-hydroxyvitamin D levels was observed in patients receiving combined anticonvulsant (phenobarbital, diphenylhydantoin, carbamazepine and acetazolamide) therapy even during 1-2 mo. after initiation of the treatment. The patients who have combined anticonvulsant therapy will apparently have more tendency to suffer from osteomalacia than those who have phenobarbital alone.

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