Hepatitis B Virus Infection

Abstract
In his review of hepatitis B virus (HBV) infection, Lee (Dec. 12 issue)1 stated that “HBV DNA can no longer be detected by any means” in patients who become negative for hepatitis B surface antigen (HBsAg) and in whom antibodies to HBsAg develop after an episode of acute hepatitis B (stage 4, or the immune stage, of HBV infection). We believe that this assertion is not in accord with recent data.2,3

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