Protease Activity on the Surface of HSV-infected Cells
Open Access
- 1 October 1979
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 45 (1) , 241-244
- https://doi.org/10.1099/0022-1317-45-1-241
Abstract
Monolayers of primary rabbit kidney cells infected with HSV type 1 bound lymphoblastoid (Raji) cells, to which the third component (C3) of the complement system had been attached (Raji-C3). This induction of cell contact did not occur on non-infected monolayers and was dependent on C3. The interaction could be suppressed by the presence of protease inhibitors (1 mm-TLCK or-PMSF). The results are interpreted as indicating de novo expression of protease activity on the surface of HSV-infected cells. This protease is characterized by its potential to activate C3 and its inhibition by TLCK.Keywords
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