Serological Analysis of the HL-A10 Complex
- 11 December 2008
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 7 (2) , 65-73
- https://doi.org/10.1111/j.1399-0039.1976.tb01034.x
Abstract
In a Caucasian blood donor population largely of Polish and German origin, W25 and W26 were shown to be distinct antigens which comprise the entire specificity of HL--A10. These antigens were in linkage disequilibrium with W18 and W16 respectively. Multiparous women with antibody against HL--A10 (W25 -- W26) had husbands typing for either W25 or W26, but never both. Other sera against HL--A11 and W32 had extra antigen reactivity with W26 and W25 respectively. Serological analysis of 21 sera with W25 and W26 reactivity suggested that the broad HL--A10 complex comprises HL--A11--W26--W25--W32. The immunolgenicity and serological reactivity of the antigens in this complex may be explained with a concept of two paired amino acid substitutions at the antigenic determinant in the HL--A peptide chain.Keywords
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