STUDIES ON EXPERIMENTAL HYPERTENSION IN THE RAT

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Abstract
Hypertension in albino rats was produced by subtotal nephrectomy. The wts. of the ovaries and thyroids of these hypertensive rats were smaller than the corresponding wts. of normal rats. The wts. of the pituitaries were not changed. The adrenals increased in wt. by a small but significant amt. The wts. of the kidneys and hearts were increased markedly. Histological sections showed nothing abnormal in the heart, thyroids or pituitaries, slight atrophy in the ovaries, some hyperplasia and vacuolization in the medulla of the adrenals, and lesions similar to chronic glomerulonephritis in the kidneys. Vaginal smears showed disturbed ovarian cycle. Hypertensive albino rats were adrenalectomized. Blood pressure fell to about the normal level after adrenalectomy. No weight changes were noticed in the endocrine glands of adrenalec-tomized as compared with hypertensive rats. The weights of the hearts and kidneys were reduced after adrenalectomy. Histological sections of endocrine glands of adrenalec-tomized rate showed the same histological picture seen in hypertensive rats. The kidneys in addition showed old glomerulonephritis and focal tubular damage. An indirect method for taking repeated blood pressure detns. in rats, by compressing the tail, was briefly described.

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