TRAIL is a key target in S-phase slowing-dependent apoptosis induced by interferon-β in cervical carcinoma cells
- 7 February 2005
- journal article
- Published by Springer Nature in Oncogene
- Vol. 24 (15) , 2536-2546
- https://doi.org/10.1038/sj.onc.1208403
Abstract
The powerful inducer of apoptosis Apo2L/TNF-related apoptosis-inducing ligand (TRAIL) has generated exciting promise as a potential tumour specific cancer therapeutic agent, since it selectively induces apoptosis in transformed versus normal cells. Interferons (IFNs) are important modulators of TRAIL expression, thus the ligand appears to play an important role in surveillance against viral infection and malignant transformation. In the light of the emerging importance of TRAIL in cancer therapy, we will discuss the molecular basis of the cooperation of TRAIL and IFNs or chemotherapeutic drugs. In particular, we will focus on the data known to date concerning the biochemical pathways leading to TRAIL-induced apoptosis in specific cancer cells and warranting further work to enable the investigation in cancer patientsKeywords
This publication has 34 references indexed in Scilit:
- Emerging Applications of the Tumor Necrosis Factor Family of Ligands and Receptors in Cancer TherapyJournal of Clinical Oncology, 2003
- Interferon-α sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-κB inactivationOncogene, 2003
- Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κBBlood, 2003
- Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatinExperimental & Molecular Medicine, 2002
- On the TRAIL to apoptosisCytokine & Growth Factor Reviews, 2002
- Antiviral response by natural killer cells throughTRAIL gene induction by IFN-α/βEuropean Journal of Immunology, 2001
- Induction of a TRAIL mediated suicide program by interferon alpha in primary effusion lymphomaOncogene, 2001
- Genomic Organization and Transcriptional Regulation of Human Apo2/TRAIL GeneBiochemical and Biophysical Research Communications, 2000
- Isolation and Molecular Characterization of the 5′-Upstream Region of the Human TRAIL GeneBiochemical and Biophysical Research Communications, 2000
- Safety and antitumor activity of recombinant soluble Apo2 ligandJournal of Clinical Investigation, 1999