Lidocaine Depresses Synaptic Activity in the Rat Hippocampal Slice

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Abstract
The direct effect of the local anesthetic lidocaine was studied using the hippocampal slice preparation in order to asses the involvement of this structure in lidocaine-induced seizure activity. Changes in the evoked field potential amplitude and latency were used to measure the effect of the drug. A dose-dependent depression of the evoked field potentials was observed at lidocaine concentration of 10-4 M and greater. No synchronized population bursting (seizures) was observed at any of the concentrations tested (10-6 M to 10-3 M). However, the hippocampal slice preparation is capable of producing seizure activity, as was demonstrated following application of penicillin G. The results suggest that the hippocampus is not the site of lidocaine-induced seizure activity.

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