Attenuation of the Activity of Caspofungin at High Concentrations against Candida albicans : Possible Role of Cell Wall Integrity and Calcineurin Pathways
Open Access
- 1 December 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (12) , 5146-5148
- https://doi.org/10.1128/aac.49.12.5146-5148.2005
Abstract
Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 μg/ml. This phenomenon was markedly attenuated in a Δ mkc1 /Δ mkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways.Keywords
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