Trypsin Shock in Frogs

Abstract
Trypsin shock was produced in frogs. The general outward behavior and the gross morphological changes found were similar to those seen in burned frogs by other investigators. Red blood cells were severely injured, as indicated by vacuolization and increased fragility. Capillary-breaking pressures, as measured by Rieser''s microinjection method, were markedly decreased. Significance of these findings is discussed with special reference to the histamine theory of shock.

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