ALZHEIMER'S DISEASE

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Abstract
The disease process first described by Alzheimer,1 and subsequently named after him by Kraepelin,2 has since received consistent, if not frequent, proof of its existence as an entity. Many cases have been described that both clinically and anatomically were so much like those described by Alzheimer and Kraepelin that, as Gruenthal3 put it, "If we were to describe as a typical case.an artificial average in which the chief features of every single case would be represented, we would hardly get anything that would differ materially from the description of any one case." The proper clinical interpretation and definition of its relation to other conditions, however, has met with difficulties, most of which have been due to the original attempt to place it among presenile diseases. Kraepelin, in the edition of his textbook published in 1922, still voiced the opinion that "although the anatomic findings in this disease