Complement-Fixing and Lymphocytotoxic Antibodies in Serum of Pregnant Women at Delivery

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Abstract
Data from an examination of 2,008 sera from parous women for lymphocytotoxic antibodies (LCTAb) and complement-fixing platelet antibodies (CFPAb) are presented. The incidence of LCTAb was 13.4% and the incidence of CFPAb 2.9%. The finding of 14 sera with CFPAb to platelets in the absence of LCTAb is discussed. It is suggested that cytotoxic antibodies belong to two different globulin classes : complementfixing cytolytic antibodies and blocking antibodies only cytolytic with rabbit complement. The incidences of CFPAb and LCTAb were found significantly lower in primparae. Smoking also seemed to depress the ability to form antibodies.

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