Putative biological functions of the DAZ family
- 6 May 2004
- journal article
- review article
- Published by Wiley in International Journal of Andrology
- Vol. 27 (3) , 125-129
- https://doi.org/10.1111/j.1365-2605.2004.00469.x
Abstract
The Deleted in Azoospermia (DAZ) gene belongs to a gene family that consists of three members: BOULE, DAZ-Like (DAZL) and DAZ. Members of the DAZ family are expressed exclusively in the germ cells, and their protein products contain a highly conserved RNA-binding motif and a unique DAZ repeat. Null mutations of the DAZ family members affect the fertility of either male or female, or both sexes. DAZ and DAZL are expressed throughout most of the life of germ cells and are required for the development of primordial germ cells and the differentiation and maturation of the germ cells. BOULE is expressed around the time of meiosis and has a more limited function. The DAZ proteins bind to RNAs in vitro and in vivo and are probably involved in the post-transcriptional regulation of mRNA expression. Their downstream RNA targets remain largely unknown, although members of the CDC25 gene family are potential candidates.Keywords
This publication has 44 references indexed in Scilit:
- Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selectionNature Genetics, 2003
- Partial rescue of the Dazl knockout mouse by the human DAZL geneMolecular Human Reproduction, 2002
- Nature of the Spermatogenic Arrest in Dazl −/− MiceBiology of Reproduction, 2001
- Four DAZ Genes in Two Clusters Found in the AZFc Region of the Human Y ChromosomeGenomics, 2000
- Expression and genetic analysis ofprtb, a gene that encodes a highly conserved proline-rich protein expressed in the brainDevelopmental Dynamics, 1999
- TheDazhGene Is Expressed in Male and Female Embryonic Gonads before Germ Cell Sex DifferentiationBiochemical and Biophysical Research Communications, 1998
- The human autosomal gene DAZLA: testis specificity and a candidate for male infertilityHuman Molecular Genetics, 1996
- A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonadHuman Molecular Genetics, 1996
- The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and prunedNature Genetics, 1996
- Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA–binding protein geneNature Genetics, 1995