Loss of Neurotropic Pathogenicity and Hemagglutinating Property of Columbia SK Virus by in vitro Cultivation in Sarcoma 180 Ascites Cells.
- 1 February 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (2) , 417-421
- https://doi.org/10.3181/00379727-109-27224
Abstract
Attenuation of Columbia SK virus by in vitro cultivation in 30 serial passages in Sarcoma 180 ascites cells is described, during which the virus lost neurotropic virulence and the HA property. Non-specific HA inhibitor in the culture medium has no connection with the changed virus nature. The attenuated virus could be used as a live vaccine for prophylaxis of Columbia SK mouse infection.Keywords
This publication has 1 reference indexed in Scilit:
- ATTENUATION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY IN VITRO CULTIVATION IN GUINEA-PIG HEART CELLS 1American Journal of Epidemiology, 1961