Synthesis of 1-C 14 -L-Ascorbic Acid
- 10 March 1950
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 111 (2880) , 257-258
- https://doi.org/10.1126/science.111.2880.257
Abstract
The synthesis involves addition of labelled cyanide to L-xylosone to form imino-L-ascorbic acid which is hydrolyzed to L-ascorbic acid in 2.6 [image] HCl at 50cC for 22 hrs. Impurities are removed by adsorption on an Amberlite ion-exchange column, followed by selective elution. The eluate containing ascorbic acid is concentrated by evaporation under N2, taken up in alcohol, subjected to ether-alcohol fractionation, and the ascorbic acid is crystallized from a methanol-ether-ligroin solvent mixture at -15[degree]C. Final yield is approx. 25%, based on the quantity of NaC14N used in the synthesis.This publication has 2 references indexed in Scilit:
- Synthese der Ascorbinsäure und verwandter Verbindungen nach der Oson‐Blausäure‐MethodeHelvetica Chimica Acta, 1934
- Synthese der d‐ und l‐Ascorbinsäure (C‐Vitamin)Helvetica Chimica Acta, 1933