Thyroid hormones regulate expression of the neural cell adhesion molecule in adult skeletal muscle
- 13 July 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 219 (1) , 135-138
- https://doi.org/10.1016/0014-5793(87)81205-x
Abstract
Adult rat skeletal muscle does not express detectable levels of neural cell adhesion molecule (N-CAM) and membrane activity mediated by nerve appears to repress the N-CAM gene. N-CAM expression in skeletal muscle can however be reinduced by hypothyroidism. Thyroidectomised rats re-express N-CAM mRNAs of 5.2 and 2.9 kb and Western blot analysis showed protein bands of 125 and 155 kDa. Immunofluorescence analysis also showed high levels of N-CAM in the sarcolemma. These changes in N-CAM expression could be reversed by treatment of hypothyroid rats with thyroxine. Thus thyroid hormones as well as neural influences appear to control N-CAM expression in skeletal muscleKeywords
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