AN ETIOLOGICAL STUDY ON RENAL ADENOMAS - WITH SOME REFERENCES TO DYSPLASTIC TUBULAR LESIONS AND ADENOCARCINOMAS IN AUTOPSY AND SURGERY CASES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 32  (4) , 585-593
Abstract
An etiological study on renal adenomas with specific references to dysplastic tubular lesions and adenocarcinomas was made, concentrating on histopathological and statistical surveys. Unilateral kidneys (72) obtained at random in autopsy cases were examined macro- and microscopically on the consecutive sliced sections. Adenomas were found frequently in the cortex of 15 cases (20.8%), and dysplastic tubular lesions were particularly associated with adenomas and detected even more frequently in 26 cases (36.1%); however, fibromas were found in the medulla of 8 cases (11.1%). Most of the adenomas (86.7%) were found in nephrosclerotic kidneys, i.e., in vascular nephrosclerosis (53.4%), in chronic pyelonephritis (13.3%) and in end-stage kidneys. The morphological feature of adenoma cells was also confirmed in the dysplastic tubular epithelial cells. Long-term renovascular and/or renostromal damages may induce dysplastic tubular lesions, and further act as important enhancing or promoting factors on adult renal oncogenesis from the cortical tubular epithelium.

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