Benzo[a]pyrene Diol Epoxide and Bleomycin Sensitivity and Susceptibility to Cancer of Upper Aerodigestive Tract

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Abstract
Cancers of the upper aerodigestive tract accounted for 3.0% of all incident cancers and 2.3% of all fatal cancers in the United States in 1997 (1). These percentages translate into 41 650 new case subjects and 12 670 deaths annually (1). Like lung cancer, cancers of the upper aerodigestive tract are paradigms of environmentally induced diseases. Although an interaction of host susceptibility to cancer and environmental exposure to carcinogens is well established in lung cancer, there are less data on susceptibility to cancer in patients with cancer of the upper aerodigestive tract.