A Study of the Immunocytoadherence Test in the Serology of Experimental Sporotrichosis

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Abstract
The immunocytoadherence (ICA) test was used for the detection of an immune response in animals with sporotrichosis. Two groups of 12 male Hartley guinea pigs, injected intrascrotally with 4 × 108 viable cells of Sporothrix schenckii and kept in a room at 10 C, developed a localized infection. Rosettes appeared during the acute stage of the infection and disappeared during the healing process. The detection of these circulating, antibody-producing cells indicated that immunoglobulins had been produced against S. schenckii. These results suggest that the ICA test warrants further investigation as a serologic method for the detection of an immunologic response in human sporotrichosis.

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