Conjugate Addition-Decarboxylation of Magnesium Monoethyl Malonate to Enones: A Convenient One-Flask Addition of Acetate

1 January 1978

journal article
research article
Published by Taylor & Francis in Synthetic Communications

Vol. 8 (1) , 53-57
https://doi.org/10.1080/00397917808062183

Abstract

We described recently¹ an improved procedure for carrying out the malonic ester synthesis whereby alkylation and decarboxylation occur in a single pot. This is accomplished by alkylating the dilithio salt of monoethyl malonic acid and then warming the resultant product.

Keywords

MAGNESIUM

This publication has 4 references indexed in Scilit:

Preparation and reactions of .beta.-chloro-.alpha.,.beta.-unsaturated ketones
The Journal of Organic Chemistry, 1976
Simple one-step alternative to the malonic ester synthesis
The Journal of Organic Chemistry, 1975
Decarbalkoxylations of geminal diesters, β-keto esters and α-cyano esters effected by sodium chloride in dimethyl sulpoxide
Tetrahedron Letters, 1973
A NEW SYNTHETIC METHOD FOR THE PREPARATION OF α-SUBSTITUTED β-KETOESTERS
Journal of the American Chemical Society, 1959