Interleukin-2 Production Is Altered by Copper Deficiency
- 27 April 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 51 (10) , 307-309
- https://doi.org/10.1111/j.1753-4887.1993.tb03062.x
Abstract
Copper is an essential nutrient for optimal function of the immune system; deficiency results in impairment of both humoral and cell-mediated components. Copper deficiency in rodents results in decreased numbers of CD4+ (helper) and total T cells. This defect has been traced to impaired production of interleukin-2, a cytokine essential for T-cell division and differentiation. Impairment of quiescent cell proliferation is reversed by both in vivo and in vitro copper supplementation.Keywords
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