Radical Surgery Versus Radiotherapy for Adenocarcinoma of the Prostate

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Abstract
Ninety-seven patients with clinical stage A2 or B (T1-2N0M0) prostatic adenocarcinoma and normal serum prostatic acid phosphatase levels, negative isotopic bone scans and no pelvic nodel extension as determined by staging pelvic lymphadenectomy were assigned randomly to radical prostatectomy or megavoltage radiation therapy. Fifty-six patients received radiation; 41 underwent radical prostatectomy. With time to first evidence of treatment failure used as the end point for determination of treatment efficacy, radical prostatectomy was more effective than megavoltage radiation in establishing disease control.