Intraductal carcinoma. Long-term follow-up after treatment by biopsy alone

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Abstract
A follow-up period averaging 21.6 yr was obtained for patients with low-grade papillary intraductal carcinoma initially treated only by biopsy between 1940 and 1950. Subsequent carcinoma was diagnosed in the same breast in 7 of the 10 patients after an average interval of 9.7 yr. Six of the 7 subsequent carcinomas were invasive. Two of the patients died of metastatic carcinoma and 2 were alive with metastases when last contacted. Three patients were without carcinoma following mastectomy. When these results were combined with the few reports available in the literature, it appeared that at least 39% of patients with intraductal carcinoma treated by biopsy alone subsequently had clinically evident carcinoma, invariably in the same breast, with an average latent period of about 10 yr. This was a result of the multicentric nature of the disease in many patients.