THE REGENERATION OF WOUNDS OF EXTERNAL MEMBRANE OF THE EYE IN THE LIGHT OF NEW PATHOLOGICO-ANATOMICAL RESULTS

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Abstract
The regeneration of the cornea and sclera following injury occurs by a proliferation of cellular forms that morphologically resemble tissue-cultures. In the periph -ery of the growing tissue, argentophyl fibrils, typical elements of a growing tissue-culture, are formed and collagenous fibres also appear. The process is unrelated to the fibro-vascular type of regeneration typical of connective tissue structures. In the cornea the wound margins may be in apposition but deeper down they become gradually separated thus forming a triangular figure of regeneration base inwards. This may be due to the elasticity of the cut Descemet''s membrane producing a gradual compression of the deeper layers because this triangular figure is not seen in scleral wounds. The process of regeneration is intense where the wound surfaces face the anterior chamber or where it comes into contact with lens substance. In these cases, the regenerating tissue extends deeply into the eye and surrounds the various structures with which it comes into contact. This fibromato-sis may cause irritation of the nervous apparatus of the eye, but pathologically it is unrelated to sympathetic ophthalmia. Atrophy of the eye or secondary glaucoma are common sequelae of extensive fibromatosis.

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