Renal damage caused by gentamicin: A study of the effects on renal morphology and urinary enzyme excretion

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Abstract
Gentamicin sulfate was administered to male Wistar rats by i.m. injection at varying dosage and for varying periods. At high dosage (50-100 mg/kg per day) gentamicin caused tubular necrosis. At dosages equivalent to that given to man (5 mg/kg per day) obvious degenerative changes were produced. Similar changes are seen in human tubular epithelium and urine deposits of patients treated with gentamicin. There is increased excretion of urinary enzymes proportional to the degree of tubular damage. The importance of these changes in man is stressed.

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