Childhood acute lymphoblastic leukemia: Results of the austrian cooperative study group with the all a 84 protocol
- 1 January 1990
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 18 (1) , 6-14
- https://doi.org/10.1002/mpo.2950180103
Abstract
We prospectively treated 127 children with ALL with a risk-adapted regimen. All patients received the identical induction-consolidation therapy. The early maintenance included intermediate dose methotrexate in patients with standard risk (n = 79) and medium risk (n = 39). In addition patients with high risk (n = 6) received high dose ARA-C followed by L-asparaginase. Intensification treatment and prophylactic cranial irradiation was also tailored according to the risk group. Treatment duration was 2 years. Complete remission was achieved in 97.6% of all patients. Treatment-related toxicity accounted for one death in complete remission. The probability of event-free survival (pEFS) for the combined group was 72% at a median follow-up of 42 months. The pEFS was higher in patients with standard risk (SR) than in patients with medium risk (MR) (80% versus 65%; p9/l had a worse prognosis than patients with a lower white blood cell count (p<0.01).Keywords
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