Renal function in patients treated with tobramycin-cefuroxime or tobramycin-penicillin G
- 1 December 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 12 (6) , 641-645
- https://doi.org/10.1093/jac/12.6.641
Abstract
In order to evaluate the potentiating effect of cefuroxime on tobramycin nephrotoxicity 21 immunocompromised patients with suspected septicaemia were randomized to treatment with either tobramycin + cefuroxime or tobramycin + penicillin G. 51Chrome-EDTA clearance, serum creatinine, serum β2-microglobulin, urinary, alanine aminopeptidase, urinary N-acetyl-β-D-glucos-aminidase and urinary β2- microglobulin were measured during a nine day course of the antibiotic combinations. Enzymuria and a small but significant decrease of 51Chrome-EDTA clearance of equal magnitude in both treatment groups occurred. However the results cannot be extrapolated to other doses and treatment times than used in the study.Keywords
This publication has 1 reference indexed in Scilit:
- Patterns of urinary β2-microglobulin excretion by patients treated with aminoglycosidesKidney International, 1980