LIVER FRACTIONS IN PERNICIOUS ANEMIA
- 22 September 1928
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 91 (12) , 867-868
- https://doi.org/10.1001/jama.1928.02700120023006
Abstract
Since Minot's1 demonstration that a diet high in liver is extraordinarily effective in treating pernicious anemia, we have been endeavoring to find whether certain constituents of liver are as effective as whole liver. We have shown2 that a 60 per cent alcoholic extract of liver evaporated to dryness and then washed with absolute alcohol and ether is effective in raising the blood count of patients with pernicious anemia in doses of from 10 to 12 Gm. daily, and that ergothioneine and spermine phosphate are not. The powder derived from the 60 per cent alcohol extraction was dissolved in water and saturated with solid ammonium sulphate. The precipitate proved inactive, but the filtrate, after the excess ammonium sulphate was removed with 60 per cent alcohol, proved active. Doses of 1.6 Gm. daily brought one patient's red cells from 1.4 to 2.7 millions in ten days, the reticulocytes reaching 380,000This publication has 1 reference indexed in Scilit:
- THE RESPONSE OF THE RETICULOCYTES TO LIVER THERAPYThe Lancet Healthy Longevity, 1928