Sarcoidal Foreign-Body Granulomatous Dermatitis Associated With Ophthalmic Drops

Publisher Website
Google Scholar
Abstract
Sarcoidal granulomas are found in sarcoidosis and in reactions to foreign materials. We report the case of an 81-year-old woman with glaucoma who presented with multiple brown-black asymptomatic papules over the chin and involving nasal mucosa and columella of 1-year duration. Biopsy of the nasal mucosa and cutaneous papules showed sarcoidal granulomas associated with brown-black intracellular pigment within multinucleated giant cells. Electron-probe x-ray microanalysis demonstrated high sulfur content. Clinical studies showed no evidence of systemic sarcoidosis. Two of three ophthalmologic drops contained sodium bisulfite; bisulfite is known to cause allergic reactions. Although the exact substance causing the granulomatous reaction is unknown, the distribution of the lesions-nasal mucosa and columella (via the nasal lacrimal duct) and the underlying chin-implicate the eyedrops in the production of the pigmented granulomatous nodules.

This publication has 31 references indexed in Scilit: