RECOMBINANT TUMOR-NECROSIS-FACTOR INHIBITS MALARIA PARASITES INVIVO BUT NOT INVITRO
- 1 January 1987
- journal article
- research article
- Vol. 67 (1) , 1-4
Abstract
As tumour necrosis serum kills malarial parasites in vitro and inhibits the multiplication of some species of Plasmodium in mice, we examined the effect of recombinant mouse tumour necrosis factor (rTNF) on Plasmodium yoelii both in vitro and in vivo. Parasites incubated overnight with rTNF showed no loss of viability, but repeated injection of rTNF into infected mice reduced parasitaemia and significantly prolonged survival of mice infected with a lethal variant of the parasite. We conclude that TNF acts on blood-stage malaria in vivo via a host cell and that another molecule in tumour necrosis serum is involved in killing the parasite in vitro.This publication has 20 references indexed in Scilit:
- Cachectin and tumour necrosis factor as two sides of the same biological coinNature, 1986
- Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.Proceedings of the National Academy of Sciences, 1986
- A comparison of eosinophil-activating factor (EAF) with other monokines and lymphokinesEuropean Journal of Immunology, 1986
- Tumor Necrosis Factor (TNF)Science, 1985
- VACCINATION WITH A PURIFIED BLOOD-STAGE MALARIA ANTIGEN IN MICE - CORRELATION OF PROTECTION WITH T-CELL MEDIATED IMMUNITY1985
- Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expressionNucleic Acids Research, 1985
- MALARIAL PARASITES AND TUMOR-CELLS ARE KILLED BY THE SAME COMPONENT OF TUMOR NECROSIS SERUM1984
- Serum containing tumor necrosis factor is cytotoxic for the human malaria parasite Plasmodium falciparumInfection and Immunity, 1983
- Differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factorInfection and Immunity, 1982
- Killing of the malarial parasite Plasmodium yoelii in vitro by cells of myeloid originParasite Immunology, 1982