Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

1 January 1989

journal article
plenary lectures
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 8 (5) , 659-671
https://doi.org/10.1080/07328318908054206

Abstract

Among the purine and pyrimidine 2′,3′-dideoxynucleosides, 2′,3′-didehydro-2′,3′-dideoxynucleosides, 3′-azido-2′,3′-dideoxynucleosides and 3′-fluoro-2′,3′-dideoxynucleosides, several congeners have been identified which achieve a potent and selective inhibition of HIV-1 replication in vitro.

Keywords

ANTI HIV
DIDEOXINUCLEOSIDE ANALOGUES
ACTIVITY RELATIONSHIP
STRUCTURE ACTIVITY
PURINE
SELECTIVE INHIBITION