Scientific evaluation of the safety factor for the acceptable daily intake (ADI). Case study: Butylated hydroxyanisole (BHA)
- 1 May 1993
- journal article
- other
- Published by Taylor & Francis in Food Additives & Contaminants
- Vol. 10 (3) , 307-314
- https://doi.org/10.1080/02652039309374153
Abstract
The principles of ‘data‐derived safety factors’ are applied to toxicological and biochemical information on butylated hydroxyanisole (BHA). The calculated safety factor for an ADI is, by this method, comparable to the existing internationally recognized safety evaluations. Relevance for humans of forestomach tumours in rodents is discussed. The method provides a basis for organizing data in a way that permits an explicit assessment of its relevance.Keywords
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