Effect of rabbit antibodies against angiotensin‐II on the pressor response to angiotensin‐II and renal hypertension in the rat

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Abstract
1 . In the intact or nephrectomized rat, the pressor responses to synthetic angiotensin-II-amide, beta-angiotensin-II and native “rat angiotensin” could be inhibited by intravenous injection of rabbit serum containing antibodies against synthetic angiotensin-II-amide. 2 . The pressor responses to vasopressin or noradrenaline were not influenced by anti-angiotensin serum. 3 . A single injection of anti-angiotensin serum inhibited the pressor responses to angiotensin-II-amide for a period of 2.5 hr. 4 . Intravenous infusion or daily intraperitoneal injection of anti-angiotensin serum did not influence blood pressure levels in renal hypertensive rats.