Effects of Asparagine and other Related Nutritional Supplements upon Alcohol-Induced Rat Liver Triglyceride Elevation

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Abstract
Male white rats which had received a single oral dose of ethanol (4.8 gm/kg of rat) showed, 16 to 18 hours later, liver triglyceride levels elevated three- to four-fold over those of control animals receiving isocaloric glucose; this triglyceride elevation was almost completely prevented by the inclusion of a supplement of L-asparagine (2 gm/kg of rat) in the ethanol solution administered. Asparagine administered separately (either 2.5 hours previously or 4 hours subsequently) from the ethanol had little effect in preventing liver triglyceride elevation; similarly ineffective was the administration, in the ethanol solution, of supplements of any of a number of other amino acids (aspartate, glutamate, glutamine, glycine, cystine, methionine) or intermediates closely related to the citric acid cycle (citrate, ketoglutarate, pyruvate). Neither asparagine nor aspartate had any effect upon liver triglyceride content of control animals receiving glucose only.

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