Role of a peptidase in phagocyte chemotaxis.
- 1 July 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (7) , 2439-2442
- https://doi.org/10.1073/pnas.73.7.2439
Abstract
The potencies of N-formylmethionyl (fMet) peptides as chemotactic agents for phagocytes [from rabbit and guinea pig peritoneal exudates] were related to the rates at which they were hydrolyzed. Furthermore, chloromethyl ketones inhibited chemotaxis as did the products of hydrolysis of fMet peptides. The directed migration of cells in response to such peptides was probably brought about by the binding of the peptide to a cell receptor with subsequent cleavage by peptidase specific for aromatic residues, a process that allows the chemical gradient to be detected.Keywords
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