HTLV-I-INDUCED LYMPHOMA MIMICKING HODGKINS-DISEASE - DIAGNOSIS BY POLYMERASE CHAIN-REACTION AMPLIFICATION OF SPECIFIC HTLV-I SEQUENCES IN TUMOR DNA

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  • 1 April 1988
    • journal article
    • research article
    • Vol. 71  (4) , 1027-1032
Abstract
A patient with a localized HTLV-I-associated lymphoproliferative disease that was misdiagnosed as Hodgkin''s disease is presented. The patient''s serum was negative for HTLV-I antibodies by enzyme-linked immunosorbent assay (ELISA), Western blot, and radioimmunoprecipitation. Tumor tissue DNA was negative for HTLV-I by Southern blotting but was positive for distinct HTLV-I sequences when subjected to DNA amplification using the polymerase chain reaction. We conclude that the clinical and pathologic diagnosis of HTLV-I-related lymphoma can be difficult and can be confused with Hodgkin''s disease. Extremely sensitive molecular biological techniques may be required to establish a diagnosis of HTLV-I-induced lymphoma.