An assessment of the effects of impaired renal function and haemodialysis on the pharmacokinetics of fluconazole.
Open Access
- 31 January 1990
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 29 (2) , 221-226
- https://doi.org/10.1111/j.1365-2125.1990.tb03623.x
Abstract
1. The oral pharmacokinetics of fluconazole were studied in three groups of volunteers (n = 5) with various degrees of renal function (GFR greater than 70 ml min-1; 20-70 ml min-1; less than 20 ml min-1) and in a group of patients with chronic end-stage renal failure requiring regular haemodialysis. 2. The pharmacokinetics of fluconazole were markedly affected by impaired renal function with the elimination of half-life in Group III (GFR less than 20 ml min-1) being approximately three times that observed in normal volunteers (Group I). 3. Fluconazole renal clearance was positively correlated with GFR. 4. Non-renal clearance of fluconazole decreased with decreasing renal function. 5. Approximately 38% of the 50 mg dose of fluconazole was removed by haemodialysis extending over a 3 h period.This publication has 1 reference indexed in Scilit:
- Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humansAntimicrobial Agents and Chemotherapy, 1985