Inhibition of acetylcholinesterase in the australian freshwater shrimp (Paratya australiensis) by profenofos

Publisher Website
Google Scholar
Abstract
Profenofos induced significant inhibitory effects on the AChE activity of Paratya australiensis ranging from >40% inhibition at sublethal concentrations of 0.1 to 1.0 μg/L to >80% inhibition at lethal concentrations of ≥10 μg/L. Sublethal chronic exposure (21 d) at a concentration of 0.15 μg/L caused persistent reduction in AChE activity of up to 60%, whereas recovery of AChE activity to normal levels from a 24‐h exposure to 0.1 μg/L profenofos required less than 9 d. Shrimp were exposed to 0.1 μg/L profenofos for 24 h and then allowed a period of recovery in pesticide‐free water; at the end of this treatment the AChE activity of affected shrimp approached control level. Subsequent 24‐h exposures with intermittent stay in pesticide‐free water for the same duration as the initial recovery phase resulted in greater inhibition in AChE activity as compared to the initial 24‐h exposure. Furthermore, the AChE activity of shrimp at the end of the recovery phases remained significantly depressed.

This publication has 29 references indexed in Scilit: