Influence of reticuloendothelial blockade on the binding of amylase to blood cells

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Abstract
Following the intravenous infusion of I131-labeled amylase into dogs and pigs, 60-80% of the enzyme is rapidly bound to blood cells. The amylase is then gradually released to the plasma so that by the end of 3 hr. only about 10% remains bound to the blood cells. In dogs whose reticuloendothelial system is blockaded by colloidal thorium dioxide (Thorotrast) only about 20-30% of the injected enzyme is quickly bound to blood cells, the remainder being distributed in the plasma. In blockaded animals no significant change in the amylase distribution between blood cells and plasma takes place during the 6-hr, experimental period. The binding and subsequent release of injected amylase from blood cells may be one of the mechanisms involved in the deposition of amylase in the liver and may also be important in the pathophysiology of pancreatitis.