Nickel penetration in allergic individuals: bioavailability versus X‐ray micro‐analysis detection

Abstract
Development of local allergic reactions after different application times with Finn Chambers was recorded in 34 Ni-sensitive patients. Biologically significant amounts of Ni seemed to penetrate the skin within a few hours, although physical penetration was minimal. Ni was detected only in the upper keratin cell layer with an X-ray microanalysis method.

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