Using SPM normalization for lesion analysis in spatial neglect

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Abstract
Traditionally, the neglect syndrome has been associated with damage to the right inferior parietal lobule (IPL) and the right temporoparietal junction (Heilman et al., 1983; Vallar and Perani, 1986). Thus, it was surprising when a recent study found that the centre of lesion overlap covered the right superior temporal gyrus and planum temporale, suggesting that the superior temporal cortex rather than the inferior parietal lobule is the critical substrate for spatial neglect in humans (Karnath et al., 2001). In that study, the authors used a new tool for lesion analysis (MRIcro; www.mricro.com), which allows more precise lesion localization than ever before. Lesions are mapped manually on a T1‐weighted template MRI that is aligned with stereotaxic space (Rorden and Brett, 2000). The template scan provides various anatomical landmarks for precisely plotting the size and localization of the lesion. Moreover, automatic three‐dimensional rendering of the lesion data derived from the transverse slices is available (Rorden and Brett, 2000). This reduces significantly the uncertainty brought in by the paper‐and‐pencil procedures used in previous anatomical studies on spatial neglect (Heilman et al., 1983; Vallar and Perani, 1986).

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