Preservation of Laryngeal Function in Patients With Carcinoma of the Larynx
- 1 June 1988
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 114 (6) , 621
- https://doi.org/10.1001/archotol.1988.01860180035025
Abstract
In an effort to preserve laryngeal function in patients with carcinoma of the larynx, Wolf et al reported on a new strategy in treatment at the recent Second International Head and Neck Oncology Research Conference held in Arlington, Va. In 1985, the Veterans Administration cooperative study program initiated a prospective, randomized multi-institutional study of the effectiveness of induction chemotherapy (CT) and radiation therapy (RT) compared with surgery and postoperative RT in patients with stage III/IV laryngeal squamous carcinoma. Induction CT (cisplatin, 100 mg/m2 administered intravenously on day 1, and fluorouracil, 1000 mg/m2 in a 24-hour infusion on days 1 through 5) was repeated on days 1, 22, and 43. Tumor response was assessed after two cycles; responders received a third cycle followed by tumor biopsy and RT (66 to 76 Gy [6600 to 7600 rad]). Patients having less than a partial response (PR) had salvage laryngectomy and RT.Keywords
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