The Structure of Bottromycin A2, a New Component of Bottromycins

1 January 1966

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 14 (9) , 981-986
https://doi.org/10.1248/cpb.14.981

Abstract

Bottromycin A2 is hydrolyzed to tetrapeptide and dipeptide by alkaline hydrolysis. The structures of both peptides are determined to be 3,3-dimethyl-2-aminobutylylvalyl-3-methylprolylglycine and 3-methyl-3-phenylalanyl-3-(2-thiazolyl)-[beta]-alanine. Hydrochloric acid hydrolysis of bottromycin A2 gives [DELTA] 1-isocaprolytetrapeptide and the structure is discussed on the bases of pKa studies. The structure of bottromycin A2 is proposed from the results above described.