Radiation Dose Fractionation and Tumor Control Probability
- 1 October 1966
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 29 (2) , 267-+
- https://doi.org/10.2307/3572011
Abstract
The effect of dose fractionation on probability of tumor cure was studied by using 4-mm3 isotransplants of the C3H mouse mammary carcinoma growing in the mouse ear. Irradiation was given in 1, 2, or 10 dose fractions, each irradiation administered under conditions of local tissue hypoxia. The TCD [tumor control dose] at 120 days after treatment was 4575, 5190, and 8400 rads. These results were interpreted as showing that the sublethal radiation energy could be rapidly and extensively repaired in the hypoxic mammary carcinoma cell of the C3H mouse. Responses of model tumors were discussed which demonstrated the impossibility of discriminating between the multitarget and the multihit response law by analysis of radiation-dose tumor-control response curves.This publication has 3 references indexed in Scilit:
- Differences in Survival Curve Shapes for Formal Multi-target and Multi-hit ModelsPhysics in Medicine & Biology, 1964
- Some Practical Considerations in Determining the Parameters for Multi-target and Multi-hit Survival CurvesPhysics in Medicine & Biology, 1964
- ACTION OF X-RAYS ON MAMMALIAN CELLSThe Journal of Experimental Medicine, 1956