Anoxia as a Factor in Resistance to Mercurial Diuretics

Publisher Website
Google Scholar
Abstract
Anoxia reduces or abolishes the natriuretic and chloruretic effect of a mercurial diuretic in dogs. That the anoxic effect is not due to the concomitant respiratory alkalosis is shown by the addition of CO2 to the inhaled low O2 gas mixture. Admn. of ACTH produces the same effect as anoxia. The anoxic effect was absent in an adrenalectomized dog. Thus, anoxia abolishes the mercurial effect via the release of adrenal cortical hormones.