Prednisone and azathioprine compared to prednisone plus low-dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis

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Abstract
A 1‐year double‐blind crossover study comparing prednisone and azathioprine to prednisone plus low‐dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low‐dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide‐induced ovarian failure and hematuria were not avoided by its use in low dose.