Assessment of Methods for Cytomegalovirus Antibody Testing of Blood Donations

Abstract
As part of a program to establish a panel of individuals with high titers of anti-cytomegalovirus (CMV) IgG for the production of CMV Ig, the CMV serostatus of 139 normal blood donors was determined by indirect hemagglutination assay, enzyme immunoassay and complement fixation. The indirect hemagglutination assay was the most accurate and convenient method for the detection of CMV antibody negative donations. Plasma for production of hyperimmune CMV IgG could best be selected by an IgG-specific enzyme immunoassay procedure.