Inhibition of Phosphatidylinositol-specific Phospholipase C Activity by Fluvirucin B2.

1 January 1995

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 48 (5) , 387-390
https://doi.org/10.7164/antibiotics.48.387

Abstract

We isolated fluvirucin B2 from the culture broth of Streptomyces as an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). It inhibited PI-PLC of A431 cell cytosol with an IC50 of 1.6 micrograms/ml. Fluvirucin B2 also inhibited PI-PLC in cultured A431 cells, whereas it did not inhibit phosphatidylinositol synthesis and macromolecular synthesis markedly. It also inhibited epidermal growth factor-induced rapid rounding of A431 cells, in which PI turnover is involved.

Keywords

STREPTOMYCES
PHOSPHOLIPASE
IC50
BROTH
FLUVIRUCIN
MICROGRAMS/ML
INHIBITION OF PHOSPHATIDYLINOSITOL
MARKEDLY

This publication has 0 references indexed in Scilit: