NMR spectroscopic analysis of neferine and isoliensinine
- 16 August 2004
- journal article
- spectral assignments-and-reference-data
- Published by Wiley in Magnetic Resonance in Chemistry
- Vol. 42 (11) , 994-997
- https://doi.org/10.1002/mrc.1469
Abstract
Neferine and isoliensinine are the two major compositions of the Chinese medicine lotus plumule. They have extensive cardiovascular activity, such as antiarrhythmic, antithrombic and antihypertensive. In order to confirm the structures reported in the literature by explicit 1H and 13C assignments, we used a series of NMR experiments including 1H, 1H‐COSY, HSQC and HMBC. The absolute configuration of neferine (C‐1 and C‐1′) was determined as R and S and that of isoliensinine (C‐1 and C‐1′) was determined as R and R. Copyright © 2004 John Wiley & Sons, Ltd.Keywords
This publication has 2 references indexed in Scilit:
- On the Alkaloids of Nelumbo nucifera GAERTN. IXYAKUGAKU ZASSHI, 1965
- Studies on the alkaloids of loti embryo. (1). Structure of isoliensinine.Tetrahedron Letters, 1964