Atopic Allergy and Serum IgE Concentrations in Randomly Selected Children Followed Up from 8 to 12 Years of Age
- 1 August 1984
- Vol. 39 (6) , 443-450
- https://doi.org/10.1111/j.1398-9995.1984.tb01966.x
Abstract
A total of 159 children selected at random were followed up from the age of 8 to 12 years regarding the development and cumulated incidence of atopic disease as well as serum IgE concentrations. The cumulated incidence, including healed cases, rose to 25.8%. The highest prevalence was found for allergic rhinitis (12.2%). Serum IgE concentrations decreased significantly in both healthy and atopic subjects, and indicated a peak in total IgE concentration in early school age. The allergy predictive value of elevated IgE concentrations was confirmed. Low concentrations of allergen-specific IgE were found in 14.1 % of children healthy before and during the observation period, indicating that transient production of IgE antibodies is a normal phenomenon. Finally, the stability of IgE was excellent during the first 2 years at −20°C but later on concentrations tended to decrease, especially in the lower range.Keywords
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